Synthesis, characterization, anti-trypanosomal activity and toxicity against Artemia salina Leach of thiobenzamides and derivatives.

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AuteurAGNIMONHAN, FINAGNON HYACINTHE
AuteurAHOUSSI, AKANNI LEON
AuteurKPOVIESSI DOSSOU, SIKA SALOME
AuteurGBAGUIDI, AHOKANNOU FERNAND
AuteurKAPANDA, N COCO
AuteurBERO, JOANNE
AuteurHANNAERT, VERONIQUE
AuteurQUETIN LECLERCQ, JOELLE
AuteurMOUDACHIROU, MANSOUROU
AuteurPOUPAERT, JACQUES H
AuteurACCROMBESSI, COFFI GEORGES
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2012
ResumeThis work aims to synthesize, characterize of thioamides benzaldehyde and 4- (dimethylamino)benzaldehyde and assess their in votrotrypanocidal activity and totoxicity. The Willgerodt-Kindler reaction preferred for the synthesis of thioamides morpholin-4-yl (phenyl) methanethione 1 and [4 - (dimethylamino) phenyl] - (morpholin-4-yl) methanethione 2, is catalyzed with montmorillonite K-10 and in a microwave oven. The structures of the thioamides were characterized and confirmed by IR spectrometry, nuclear magnetic resonance (1H and 13C NMR) and mass spectrometry (MS) Their trypanocidal activity was evaluated in the blood stream form of the strain of Trypanosoma brucei brucei 427 using the "Lilit, Alamar Blue" (Baltz et al., 1985; Hirumi et al., 1994; Räz et al., 1997) and cytotoxicity on brine shrimp larvae (Artemia salina Leach) using the method of Michael et al. (1956) resumed by Vanhaecke et al. (1981) and Sleet and Brendel (1983). The compounds1 (IC50> 483.09 M) and 2 (IC50> 400 M) have weak trypanocidal activities. However the larvae were sensitive to 2 (LD50 = 214 ± 9 M) and therefore it could be used in cancer treatment.
DOI10.7324/JAPS.2012.2601
Autre identifiantBECDB-11473
URIhttps://dspace.uac.bj/handle/123456789/10087
Languefr
Fait partie deJournal of Applied Pharmaceutical Science
SujetWillgerodt-Kindler
SujetMontmorillonite K-10
Sujetmorpholin-4-yl (phenyl)-methanethione
Sujet[4-(di-methylamino) phenyl] (morpholin-4-yl) methanethione
SujetArtémia salina Leach
Sujettrypanocidal
TitreSynthesis, characterization, anti-trypanosomal activity and toxicity against Artemia salina Leach of thiobenzamides and derivatives.
TypeArticle

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