Spasmolytic effects of aqueous extract of mixture from Aframomumummelegueta(K Schum) – Citrus aurantifolia (Christm and Panzer) on isolated trachea from Rat

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AuteurAHOUNOU AIKPE, FIFAMIN JUDITH
AuteurOUEDRAOGO, GEOFROY
AuteurGBENOU, J
AuteurOUEDRAOGO, SOSTHENE ACHILLE
AuteurAGBODJOGBE, WILFRID KPEDETIN DIEUDONNE D
AuteurDANSOU, PIERRE HOUNDJOVI
AuteurMOUDACHIROU, MANSOUROU
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2012
ResumeThe spasmolytic properties of the aqueous extract of Aframomum melegueta (K Schum) and Citrus aurantifolia (Christm and Panzer) (AMCA) mixture were tested on isolated rat trachea. Inhibition of the contraction was observed the in presence of the AMCA (EC 50 = 1.80 ± 0.48 mg/mL) after a pre contraction of the trachea by acetylcholine (10 -5 M). With propranolol (10 -6 M), the spasmolytic activity of the mixture was inhibited and the concentration-response curve shifted to the right. The EC50 value was then 2.60 ± 0.41 mg/mL. AMCA also inhibited contraction induced by KCl (4.10 -2 M) with EC50 value = 1.86 ± 0.65 mg/mL. These results clearly show the relaxing effect of the aqueous extract on the isolated rat trachea. This effect involved some β-adrenergic receptor inhibition.
Autre identifiantISSN : 0189-6016 www.ajol.info/index.php/ajtcam journals.sfu.ca/africanem/index.php/ajtcam
URIhttps://dspace.uac.bj/handle/123456789/1889
Languefr
Fait partie deAfr. J. Tradit,.Complemenary. Altern. Med., 2012
SujetKey words: Aframomum melegueta
SujetCitrus aurantifolia
Sujetextract
Sujetbronchodilatory
Sujetspasmolytic
SujetRat trachea
TitreSpasmolytic effects of aqueous extract of mixture from Aframomumummelegueta(K Schum) – Citrus aurantifolia (Christm and Panzer) on isolated trachea from Rat
TypeArticle

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