Impact of a high-calorie diet on liver and kidneys in Wistar rats

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AuteurBEHANZIN, GBESSOHELE JUSTIN
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2023
ResumeObesity is a scourge of international public order and is accompanied by an impressive set of health issues, including pathologies related to the kidneys and liver. In our study, it was a question of setting up an experimental obesity model in order to evaluate the impact of the latter on the liver and kidneys of the Wistar rat. The rats were fed a high-calorie diet for 30 days. At the end of the trial, blood samples were taken for the determination of tissue lipids; the animals were then sacrificed, and their kidneys and livers were removed for histological examinations. The results revealed a significant increase in the biological markers of the liver (AST, ALT, PAL, and GGT) and those of the kidneys (uremia, uricemia, and creatinine) in the rats subjected to such a diet, thus highlighting the dysfunction of the liver and kidneys. Furthermore, histological examinations revealed no signs of damage to these organs. However, a significant increase in tissue lipids is noted. The high-calorie diet, therefore, caused an accumulation of fat in the liver and kidneys of the rats. This accumulation could reflect the onset of hepatic steatosis (fatty liver disease) in rats.
Autre identifiantBECDB-14991
URIhttps://dspace.uac.bj/handle/123456789/12748
Languefr
Fait partie deInternational Journal of Biosciences | IJB |
SujetHigh-calorie diet
SujetObesity
SujetFats
SujetFatty liver disease
TitreImpact of a high-calorie diet on liver and kidneys in Wistar rats
TypeArticle

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