Effect of cyclodextrins on artemisinin stability and in vitro dissolution

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AuteurZIME DIAWARA, HERMINE
AuteurGBAGUIDI, AHOKANNOU FERNAND
AuteurSEMDE, RASMANE
AuteurSOME, ISSA
AuteurQUETIN LECLERCQ, JOELLE
AuteurMOUDACHIROU, MANSOUROU
AuteurPIEL, GERALDINE
AuteurEVRARD, BRIGITTE
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2013
ResumeArtemisinin is extracted from the Asian plant Artemisia annua L. It has been proven to be, with its derivatives, the molecules that have shown so far the most powerful activity on malaria, even in its complicated forms and resistance cases. To resolve the problem of low aqueous solubility of this molecule, the use of cyclodextrins (CDs) was envisaged and gave good results in this topic. However, the impact on its stability and in vitro dissolution, important parameters for drug formulation and evaluation, was not evaluated. In this study, stability in accelerated degradation conditions and in vitro dissolution analysis of artemisinin were performed in comparison with complexes of artemisinin and cyclodextrins. The findings of this work allowed us to suggest that CDs improve the stability of artemisinin, especially when it’s in aqueous solution. We also demonstrated the beneficial impact of cyclodextrins on the in vitro dissolution of artemisinin from capsules prepared with rough extracts of A. annua.
Autre identifiantBECDB-1637
URIhttps://dspace.uac.bj/handle/123456789/1773
Languefr
Fait partie deInt. J. Biol. Chem. Sci.
SujetArtemisia annua capsules
SujetMalaria
Sujetlyoequivalence
Sujetdissolution apparatus
Sujetstorage conditions
TitreEffect of cyclodextrins on artemisinin stability and in vitro dissolution
TypeArticle

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