Synthesis of antitrypanosomal thiosemicarbazones using anthranilic acid as an innovative Green nucleophilic catalyst

Simple item page
AuteurKASSEHIN, URBAIN C
AuteurGBAGUIDI, AHOKANNOU FERNAND
AuteurMCCURDY, CHRISTOPHER R
AuteurPOUPAERT, JACQUES H
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2014
ResumeTrypanosomiasis constitutes a severe health problem for sub-saharian African and latin American population and there is an urgent need for better drugs to cure this life-threatening disease. In this context, aromatic thiosemicarbazones appears attractive drug candidates. The condensation reaction of thiosemicarbazides with aldehydes and ketone to form thiosemicarbazones is very efficiently catalyzed by nucleophilic catalysis in the general context of generalized acid-base catalysis. In this paper, we developed anthranilic acid as a general purpose green catalyst. Methanol appears to be a performants solvent for this reaction. In general, good to excellent yields in the range of 70-99% were obtained. In the condensation of various ketones with 4-phenylthiosemicarbazide the choice of anthranilic acid as catalyst was rationalized on the basis of mechanistic considerations
Autre identifiantBECDB-1591
URIhttps://dspace.uac.bj/handle/123456789/1729
Languefr
Fait partie deJournal of Chemical and Pharmaceutical Research
SujetGreen chemistry
SujetNucleophilic Catalysis
Sujettrypanosomal infections
Sujetthiosemicarbazones
Sujetanchimeric assistance
TitreSynthesis of antitrypanosomal thiosemicarbazones using anthranilic acid as an innovative Green nucleophilic catalyst
TypeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
93c81078b1cc48591850b4b4b103ad00.pdf
Size:
114.05 KB
Format:
Adobe Portable Document Format
Download

Collections

Articles