Volatile oil composition and antiproliferative activity of Hyptis spicigera Lam against human breast adenocarcinoma cells MCF-7.
| Auteur | BOGNINOU AGBIDINOUKOUN, G SOPHIE REINE | |
| Auteur | YEDOMONHAN, HOUNNANKPON | |
| Auteur | AVLESSI, FELICIEN | |
| Auteur | SOHOUNHLOUE, KOKO CODJO DOMINIQUE | |
| Auteur | CHALARD, PIERRE | |
| Auteur | CHALCHAT, JEAN C | |
| Auteur | DELORT, LAETICIA | |
| Auteur | BILLARD, HERMINE | |
| Auteur | CALDEFIE CHEZET, FLORENCE | |
| Auteur | FIGUEREDO, GILLES | |
| Date d'ajout | 2026-06-02T16:06:57Z | |
| Date de disponibilite | 2026-06-02T16:06:57Z | |
| Date de publication | 2013 | |
| Resume | This study reported the chemical composition and the evaluation of the in vitro antiproliferative activity of volatile extracts of Hyptis spicigera (HS) on breast cancer cells MCF-7. Essential oils (EO) HS1 and HS2 extracted from leafy stems of H. spicigera by hydrodistillation after different harvesting periods were characterized by gas chromatography/flame ionization detector (GC/FID) and gas chromatography/mass spectrometry (GC/MS). The cytotoxicity of these volatile extracts was tested in order to assess their antiproliferative activity on cancer cells MCF-7 by the resazurin test. Chromatographic analysis revealed several major compounds depending on the harvest period of vegetable. Sample HS1 was characterized by α-pinene (16.9%), sabinene (13.8%), β-pinene (9.6%) and 1,8-cineole (9.6%), while HS2 was potentially rich in β- caryophyllene (53.2%), caryophyllene oxide (5.4%) and α-humulene (3.8%). Biological investigations performed have shown that HS1 and HS2 were cytotoxic against MCF-7 cells. Inhibitory concentrations values (IC50 ) determined for this purpose were 170 and 84 µg/mL respectively for HS1 and HS2. Major compounds of the EO should be responsible for this inhibitory activity. | |
| Autre identifiant | BECDB-1856 | |
| URI | https://dspace.uac.bj/handle/123456789/1943 | |
| Langue | fr | |
| Fait partie de | Research Journal of Chemical Sciences | |
| Sujet | Hyptis spicigera | |
| Sujet | volatile extract | |
| Sujet | MCF-7 | |
| Sujet | β-caryophyllene | |
| Sujet | α-pinene | |
| Sujet | Bénin | |
| Titre | Volatile oil composition and antiproliferative activity of Hyptis spicigera Lam against human breast adenocarcinoma cells MCF-7. | |
| Type | Article |
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