Antimalarial action of aqueous and hydro alcoholic extracts of Artemisia annua L. cultivated in Benin: In vitro and in vivo studies.

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AuteurZIME DIAWARA, HOUETCHEGBE HERMINE GANI
AuteurGANFON, MEDESSOU YOWEL HABIB
AuteurYEMOA, LOCONON Y ACHILLE
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2015
ResumeThe aqueous and hydro alcoholic extracts of Artemisia annua plants acclimatized and set in culture in Benin, were investigated for their in vitro and in vivo antimalarial value. These extracts were prepared by decoction and maceration using water and ethanol, and were tested for in vitro activity against the strains of Plasmodium falciparum. Those extracts were also investigated in vivo against Plasmodium berghei NK 173 infected mice by the 4-day suppressive test. The action of these extracts was similar in vitro to the action of pure artemisinin at the same dosage. But, the in vivo studies on mice show that we have the same efficacy with aqueous extract of A. annua (artemisinin content of 20 mg/kg) than with pure artemisinin at a dosage of 140 mg/kg. The hydro alcoholic extract of A. annua (artemisinin content of 20 mg/kg) was better than the both other conditions. The others components of the plant Artemisia annua potentiate artemisinin activity on Plasmodium. The aqueous and hydro alcoholic extracts of Artemisia annua L. are very effective on malaria and they can be used by populations to cure this disease, especially in endemic areas where modern medicines are expensive.
Autre identifiantBECDB-4429
URIhttps://dspace.uac.bj/handle/123456789/4207
Languefr
Fait partie deJournal of Chemical and Pharmaceutical Research
SujetArtemisia annua extracts
Sujetin vitro studies
Sujetin vivo studies
Sujetartemisinin potentiation
TitreAntimalarial action of aqueous and hydro alcoholic extracts of Artemisia annua L. cultivated in Benin: In vitro and in vivo studies.
TypeArticle

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