Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice

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AuteurFACHINAN, RUFINE
AuteurFAGNINOU, ADNETTE
AuteurNEKOUA, P MAGLOIRE
AuteurAMOUSSA, A MADJID
AuteurADJAGBA, MARIUS
AuteurLAGNIKA, LATIFOU
AuteurLALEYE, OLABISSI ANATOLE A
AuteurMOUTAIROU, KABIROU
AuteurYESSOUFOU, AKADIRI A RACHIDI
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2017
ResumeThe mechanism of action of the antidiabetic capacity of Momordica charantia is still under investigation. Here, we assessed phytochemical compositions, antioxidant activity, and effects of total and filtered fruit and leafy stem juices of Momordica charantia on human T cell proliferation and differentiation through quantification of Th1/Th2 cytokines. In the absence of stimulation, total fruit and leafy stem juices induced significant T cell proliferation. Under PHA stimulation, both juices potentiated plant-induced T cell proliferation. However, the filtered fruit and leafy stem juices significantly inhibited PHA-stimulated T cell proliferation, while neither juice influenced T cell proliferation. Moreover, total and filtered fruit juice increased IL-4 secretion, while total and filtered leafy stem juice enhanced IFN-γ production. Phytochemical screening revealed the presence of tannins, flavonoids, anthocyans, steroids, and triterpenoids in both juices. Alkaloids, quinone derivatives, cardenolides, and cyanogenic derivatives were undetectable. The saponins present in total juices were undetectable after filtration. Moreover, both juices had appreciable antioxidant capacity. Our study supports the type 1 antidiabetic effect of filtered fruit juice of M. charantia which may be related to its immunosuppressive and T-helper 2 cell inducing capacities. Due to their immune-stimulatory activities and their ability to increase T-helper 1 cell cytokines, total fruit and leafy stem juices may serve in the treatment of immunodeficiency and certain infections.
DOI10.1155/2017/9478048
Autre identifiantBECDB-8651
URIhttps://dspace.uac.bj/handle/123456789/7766
Languefr
Fait partie deBioMed Research International
SujetMomordica charantia
SujetDiabetes
SujetT-cell proliferation
SujetTh1/Th2 cytokines
TitreEvidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice
TypeArticle

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