Phytochemical Profile and Antioxidant Potential of 12 Antimalarial Recipes Used in Lacustrine Areas In Benin

Abstract

The present work aims to identify the major chemical groups and to evaluate the anti-radical activity of 12 recipes of medicinal plants used in the treatment of malaria among children, pregnant women and adults in two lake villages (Ganvi , Aguegues Daho) of southern Benin. All the recipes contain molecules able to trap the 2,2-diphenyl-1-picrylhydrazyl (DPPH) which is a free radical. This activity would be due to the phenolic compounds identified in the phytochemical screening and whose presence in these recipes has been confirmed by quantitative test performed in a spectrophotometer. Aqueous extract obtain by decoction of recipes 3, 1 and 4 (E3, E1, E4) of the child have the higher contents of total phenolics compounds and good anti-radical activity compared to other extracts. The aqueous extract obtain by decoction of the recipe 3 which has the strongest content of total polyphenols (668.16 mg EAG/g DM) was the most active for trapping DPPH with an IC50 of 0.095 mg/mL similar to those of butylated hydroxyanisole (0.090 mg/mL) and quercetin (0.100 mg/mL) that are reference antioxidants used in this study. These results justify the use of these traditional recipes.