Trypanocidal activity of a thioacyl-thiosemicarbazide derivative associating both immunostimulating thalidomide and anti-parasitic thiosemicarbazide pharmacophores

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AuteurKASSEHIN, URBAIN C
AuteurGBAGUIDI, AHOKANNOU FERNAND
AuteurMCCURDY, CHRISTOPHER R
AuteurPOUPAERT, JACQUES H
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2015
ResumeAfrican trypanosomiasis remains a life-threatening disease and there is nowadays an urgent need for improved therapeutic agents for this pathology. In this context, in order to create novel anti-protozoa prototype containing both a trypanocidal thiosemicarbazide moiety and an immuno-potentiating thalidomide-like, a hybrid structure was designed on the basis of a convergent synthesis process, synthesized and assayed for its potential trypanocidal activity. Initial biological results are very promising. The structure of the target compound was ascertained on the basis of 13C-NMR, IR spectroscopy and semi-empirical AM1/PM3 quantum-mechanical calculations
Autre identifiantBECDB-1588
URIhttps://dspace.uac.bj/handle/123456789/1726
Languefr
Fait partie deJournal of Chemical and Pharmaceutical Research
SujetTrypanocidal activity
Sujetimmunostimulating thalidomide
Sujetthioacyl-thiosemicarbazide
Sujetthiosemicarbazide pharmacophore
SujetSchotten-Baumann thioacylation reaction
TitreTrypanocidal activity of a thioacyl-thiosemicarbazide derivative associating both immunostimulating thalidomide and anti-parasitic thiosemicarbazide pharmacophores
TypeArticle

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