APOPTOTIC ACTION OF ETHANOLIC EXTRACTS OF THE LEAVES OF HEXALOBUS MONOPETALUS (ANNONACEAE) ON CERVICAL CANCER IN WISTAR RATS

Abstract

Across the world, the search for new anti-cancer molecules remains one of the main concerns of oncology researchers. Also, plants have been at the origin of many active molecules having shown their effectiveness in the treatment of different cancers (MERGHOUB N., 2011). In Benin, traditional medicine, rich and diversified, is an important source for the screening of new therapeutic molecules. The aim of our study is to determine the apoptotic action of the ethyl extract of the leaves of Hexalobus monopetalus on cervical cancer in wistar rats. The total proteins were assayed to the spectrophotometer in the blood after induction of cervical cancer with Cycas revoluta in three batches of three rats each. Once the cancer is induced, the dose of 2.5 mg / kg body weight of the ethyl extract of the leaves of Hexalobus monopetalus diluted in 1 ml of 33% ethanol is administered to three batches of two rats each. The biochemical parameters of total proteins and alkaline phosphatase were measured on the tissues of the cervix. It emerges from our work that Cycas revoluta has a proliferative action on the tissues of the cervix. Also, the ethyl extract of the leaves of Hexalobus monopetalus increases the level of total proteins and lowers the alkaline phosphatase level on cervical tissues. Hexalobus monopetalus would have an antiproliferative action on cancer cells of the cervix.