Chemical composition,cytotoxicityand in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin

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AuteurKPOVIESSI, DOSSOU SIKA SALOME
AuteurBERO, JOANNE
AuteurAGBANI, PIERRE ONODJE
AuteurGBAGUIDI, AHOKANOU FERNAND
AuteurKPADONOU KPOVIESSI, BENEDICTA
AuteurSINSIN, BRICE AUGUSTIN
AuteurACCROMBESSI, COFFI GEORGES
AuteurFREDERICH, MICHEL
AuteurMOUDACHIROU, MANSOUROU
AuteurQUETIN LECLERCQ, JOELLE
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2014
ResumeEthnopharmacological relevance:Cymbopogon species arelargelyusedinfolkmedicineforthetreatment of manydiseasessomeofwhichrelatedtoparasiticaldiseasesasfeversandheadaches.Aspartofour researchonantiparasiticessentialoilsfromBenineseplants,wedecidedtoevaluatethe in vitro antiplasmodial andantitrypanosomalactivitiesofessentialoilsoffour Cymbopogon species usedin traditional medicineaswellastheircytotoxicity. Materials andmethods: The essentialoilsoffour Cymbopogon species Cymbopogon citratus (I), Cymbopogon giganteus (II), Cymbopogon nardus (III) and Cymbopogon schoenantus (IV) fromBenin obtained byhydrodistillationwereanalysedbyGC/MSandGC/FIDandweretested in vitro against Trypanosomabruceibrucei and Plasmodium falciparum respectivelyforantitrypanosomalandantiplas- modial activities.Cytotoxicitywasevaluated in vitro against ChineseHamsterOvary(CHO)cellsandthe human noncancer fibroblastcellline(WI38)throughMTTassaytoevaluatetheselectivity. Results: All testedoilsshowedastrongantitrypanosomalactivitywithagoodselectivity.SampleIIwas the mostactiveagainst Trypanosomabruceibrucei and couldbeconsideredasagoodcandidate.Itwas less activeagainst Plasmodium falciparum. SamplesII,IIIandIVhadlowornocytotoxicity,butthe essential oilof Cymbopogon citratus (I), wastoxicagainstCHOcellsandmoderatelytoxicagainstWI38 cells andneedsfurthertoxicologicalstudies.SampleI(29compounds)wascharacterisedbythepresence as mainconstituentsofgeranial,neral, β-pinene and cis-geraniol;sampleII(53compounds)by trans-pmentha- 1(7),8-dien-2-ol, trans-carveol, trans-p-mentha-2,8-dienol, cis-p-mentha-2,8-dienol, cis-pmentha- 1(7),8-dien-2-ol, limonene, cis-carveol and cis-carvone; sampleIII(28compounds)by β- citronellal, nerol, β-citronellol, elemolandlimoneneandsampleIV(41compounds)bypiperitone, (þ)-2-carene, limonene,elemoland β-eudesmol. Conclusions: Our studyshowsthatessentialoilsof Cymbopogon genus canbeagoodsourceof antitrypanosomal agents.Thisisthe first reportontheactivityoftheseessentialoilsagainst Trypanosomabruceibrucei, Plasmodium falciparum and analysisoftheircytotoxicity.
DOI10.1016/j.jep.2013.11.027
Autre identifiantBECDB-1605
URIhttps://dspace.uac.bj/handle/123456789/1742
Languefr
Fait partie deJournal of Ethnopharmacology
SujetCymbopogon species
Sujetessential oils
Sujetchemical composition
SujetAntitrypanosomal activity
SujetAntiplasmodial activity
Sujetcytotoxicity
TitreChemical composition,cytotoxicityand in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin
TypeArticle

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