Isolation and Identification of Two Antibacterial Agents from Chromolaena odorata L. Active against Four Diarrheal Strains
| Auteur | LAGNIKA, LATIFOU | |
| Auteur | ATINDEHOU, MENONVE MEGNISSE | |
| Date d'ajout | 2026-06-02T16:06:57Z | |
| Date de disponibilite | 2026-06-02T16:06:57Z | |
| Date de publication | 2013 | |
| Resume | Chromolaena odorata L (Asteraceae) is a bad invasive plant, found in the humid tropics and sub-tropics worldwide. It is used against dysentery, diarrhea, malaria, wound healing, headache and toothache in traditional medicine. In the pre- sent study, we investigated the antibacterial activities of different leaves extracts of Chromolaena odorata L. (cyclo- hexane, dichloromethane, ethyl acetate and butanol) against four clinical diarrheal strains (Klebsiella oxytoca, Salmo- nella enterica, Shigella sonnei and Vibrio cholera). We demonstrated that C. odorata leaves extracts show an antibacte- rial activity between 0.156 and 1.25 mg/mL. Bioassay-guided chromatography by bioautography with iodonitrotetra- zolium-based colorimetric assay allowed the isolation and identification of two active compounds. After the combina- tion of RP-HPLC, mass spectrometry analysis, 1D and 2D-NMR spectroscopy, we isolated and characterized two active molecules corresponding to 3’,4’,5,6,7-Pentamethoxyflavone (Sinensetin) and 4’,5,6,7-Tetramethoxyflavone (Scutel- lareintetramethyl ether). | |
| DOI | 10.4236/aim.2013.31018 | |
| Autre identifiant | BECDB-1877 | |
| URI | https://dspace.uac.bj/handle/123456789/1959 | |
| Langue | fr | |
| Fait partie de | Advances in Microbiology | |
| Sujet | Chromolaena odorata | |
| Sujet | 3’ | |
| Sujet | 4’ | |
| Sujet | 5 | |
| Sujet | 6 | |
| Sujet | 7-Pentamethoxyflavone (Sinensetin) | |
| Sujet | 7-Tetramethoxyflavone (Scutellareintetramethyl ether) | |
| Sujet | antibacterial activity | |
| Sujet | Diarrheal Strains | |
| Titre | Isolation and Identification of Two Antibacterial Agents from Chromolaena odorata L. Active against Four Diarrheal Strains | |
| Type | Article |
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