Effects of crude aqueous extracts of Heliotropium indicum Linn (Boraginaceae) on blood pressure in Wistar rats

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AuteurADJAGBA, MARIUS
AuteurAWEDE, BONAVENTURE L SEVERIN
AuteurOSSENI, S D
AuteurDOUGNON, GOFRIED
AuteurDOSSEH, WALLIS
AuteurLAGNIKA, LATIFOU
AuteurDARBOUX, RAPHAEL BARTHELEMY
AuteurLALEYE, OLABISSI ANATOLE A
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2017
ResumeThe present work was carried out to investigate the effects of crude aqueous extracts of the stem with leaves and roots of Heliotropium indicum Linn on blood pressure in Wistar rats. Crude aqueous extracts were obtained by decoction of Heliotropium indicum stem with leaves and roots. A phytochemical screening of extracts has been made by thin layer chromatography. The pharmacological effect of the extracts was assessed by administration to L-NAME-induced hypertensive Wistar rats. Blood pressures were measured by carotid catheterization. The chemical screening revealed the presence of many secondary metabolites such as coumarins, flavonoids, anthocyanics, lignans, saponins, tannins, terpenes and triterpenes in both extract. Alkaloid were detected only in the root extract.7-days administration of L-NAME induced an increase is of rat mean arterial pressure (MAP) from 106±3 mmHg to 134±2 mmHg. Administration of both extracts significantly decreased the MAP from 134±2 mmHg to respectively to 108 ±1 mmHg for the stem with leaf extract and to 121±2 mmHg for the root extract. These results provide a support for the use of this plant in traditional medicine.
DOI10.7439/ijpr.v7i8.4295
Autre identifiantBECDB-17638
URIhttps://dspace.uac.bj/handle/123456789/14612
Languefr
Fait partie deInternational Journal of Pharmacological Research
SujetHeliotropium indicum Linn
SujetHypertension
SujetWistars rats
SujetL-NAME
TitreEffects of crude aqueous extracts of Heliotropium indicum Linn (Boraginaceae) on blood pressure in Wistar rats
TypeArticle

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