High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin

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AuteurALAO, MODJERE OLA MAROUFOU JULES
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2014
ResumeLoss of endothelial protein C receptor (EPCR) occurs at the sites of Plasmodium falciparum–infected erythrocyte sequestration in patients with or who died from cerebral malaria. In children presenting with different clinical syndromes of malaria, we assessed the relationships between endogenous plasma soluble EPCR (sEPCR) levels and clinical presentation or mortality. After adjustment for age, for treatment before admission, and for a known genetic factor, sEPCR level at admission was positively associated with cerebral malaria (P = .011) and with malaria-related mortality (P = .0003). Measuring sEPCR levels at admission could provide an early biological marker of the outcome of cerebral malaria.
DOI10.1093/infdis/jiu661
Autre identifiantBECDB-4569
URIhttps://dspace.uac.bj/handle/123456789/4306
Languefr
Fait partie deJournal of Infectious Diseases
SujetPlasmodium
Sujetcerebral malaria
SujetEPCR
SujetsEPCR
Sujetprotein C
TitreHigh plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin
TypeArticle

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