The Action of Aqueous Extracts of the Bark of the Trunk of Sclerocarya birrea on the Proliferation of Hepatic Cells Induced by Cycas revoluta

Abstract

The purpose of this work is to examine the action of aqueous extracts of the bark of the trunk of Sclerocarya birrea on the proliferation of liver cells. For this purpose, an aqueous extraction is carried out by maceration with the dried bark powder of the trunk of Sclerocarya birrea. Then we carried out the phytochemical screening of the bark of the plant by the method of Houghton and Raman. Finally, the antiproliferative activity is evaluated by assaying the biochemical parameters Alanine Amino Transferase (ALAT), Aspartate Amino Transferase (ASAT) and total proteins in the blood and on the liver broths of the Wistar rats put under experimentation. Proliferation is induced by exposure of rats to Cycas revoluta powder through a 5% diet of this powder and a drinking water containing 10 mg/kg of the same powder and the antiproliferative activity is carried out by Administration of a daily dose of 100mg / kg of aqueous extracts of the bark of the trunk of Sclerocarya birrea. The results of the phytochemical screening revealed the presence of several chemical compounds: catechic tannins, flavonoids, leucoanthocyanins, anthraquinones, alkaloids, mucilages and phenol. These chemical compounds with various properties are found at various concentrations. The antiproliferative activity is effective and shows a variation in intensity according to the mode and the duration of administration.