Anti-Tuberculosis Drugs-Induced Pellagrous Erythema

Abstract

Pellagra is a deficient disease due to deficit in vitamin PP or niacin. It is characterized by the “3D” classic syndrome: photo-distributed dermatitis termed early and frequent “pellagrous erythema”, chronic diarrheal and an advanced stage dementia. The main aetiologies are: nutritional deficiencies in niacin, chronic alcoholism, gastrointestinal malabsorption disorders. Some medicines may engender vitamin PP deficiency by competitive inhibition on the target cells of vitamin PP and the synthesis of niacin through its binding to vitamin B6. We report a case of early pellagra in the form of pellagrous erythema with anti-tuberculosis drug.