Direct assessment of body iron balance in women with and without iron supplementation using a long-term isotope dilution method in Benin and Switzerland

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AuteurSPEICH, CORNELIA
AuteurMITCHIKPE, COMLAN EVARISTE SIMON
AuteurCERCAMONDI, COLIN I
AuteurZEDER, CHRISTOPHE
AuteurBRITTENHAM, GARY M
AuteurMORETTI, DIEGO
AuteurZIMMERMANN, MICHAEL B
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2021
ResumeBackground: Long-term isotopic dilution measurements of body iron may allow quantification of basal body iron balance and iron gains during an iron intervention with higher precision and accuracy than conventional iron indices. Objectives: We compared body iron balance before, during, and after oral iron supplementation in women in Benin and in Switzerland. Methods: In prospective studies, Beninese (n = 11) and Swiss (n = 10) women previously labeled with stable iron isotopes were followed preintervention for 90–120 d, then received 50-mg iron daily for 90–120 d and were followed postintervention for 90–120 d. We used changes in blood isotopic composition to calculate iron absorption (Feabs), iron loss (Feloss), and net iron balance (Fegain). Results: Compliance with supplementation was >90%. In Benin, during the preintervention, intervention, and postintervention periods, Fe means ± SDs were as follows: 1) Feabs : 0.92 ± 1.05, 3.75 ± 2.07, and 0.90 ± 0.93 mg/d; 2) Feloss : 1.46 ± 1.95, 1.58 ± 1.57, and 1.84 ± 1.61 mg/d; and 3) Fegain: −0.55 ± 1.56 mg/d, 2.17 ± 1.81 mg/d, and −0.94 ± 1.13 mg/d. In Switzerland, the corresponding values were: 1) 1.51 ± 0.37, 4.09 ± 1.52, and 0.97 ± 0.41 mg/d; 2) 0.76 ± 1.37, 2.54 ± 1.43, and 2.08 ± 1.05 mg/d; and 3) 0.75 ± 1.37, 1.55 ± 1.75, and −1.11 ± 1.06 mg/d. Inflammation was low in both settings, and isotopically calculated iron balance was comparable to that calculated from changes in conventional iron indices. Conclusion: Without iron supplementation, Beninese women had lower long-term dietary iron absorption and higher iron losses in the preintervention period than Swiss women. During iron supplementation, both groups had high iron absorption and similar iron gains. However, there was a 3-fold increase in iron losses in the Swiss women during the supplementation and postintervention period compared with the preintervention period. Body iron isotope dilution is a promising new method for quantifying long-term body iron balance and for assessing the impact of iron interventions. The studies were registered at clinicaltrials.gov as NCT02979080 and NCT02979132, respectively.
DOI10.1093/ajcn/nqaa433
Autre identifiantBECDB-16193
URIhttps://dspace.uac.bj/handle/123456789/13621
Languefr
Fait partie deAmerican Journal of Clinical Nutrition
Sujetiron absorption
Sujetiron loss
Sujetiron balance
Sujetiron supplementation
SujetWomen
Sujetiron stable isotopes
SujetBénin
SujetSwitzerland
TitreDirect assessment of body iron balance in women with and without iron supplementation using a long-term isotope dilution method in Benin and Switzerland
TypeArticle

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