N,Ndimethylformamide.diiodine complex (DMF.I2) as an innovative efficient green catalyst in the synthesis of thiosemicarbazones by condensation of ketones with thiosemicarbazides

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AuteurKASSEHIN, URBAIN C
AuteurGBAGUIDI, AHOKANOU FERNAND
AuteurMCCURDY, CHRISTOPHER R
AuteurPOUPAERT, JACQUES H
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2015
ResumeIn a drug discovery program aimed at finding new anti-trypanosomal drugs, we developed the N, Ndimethylformamide.diiodine complex (DMF.I2) as an innovative and efficient green catalyst for the condensation reaction of aldehydes/ketones with arylthiosemicarbazides. The design of this catalyst was rationalized on the basis of a mechanistic proposal which establishes the existence of a catalytic loop regenerating I2 at the end of the catalytic process. In general, yields were fair to good at extremely low end catalyst concentration. DMF.I2 is the first catalyst that allows for high yield in the condensation of aldehydes/ketones with arylthiosemicarbazide at sub-micromolar concentration.
Autre identifiantBECDB-1584
URIhttps://dspace.uac.bj/handle/123456789/1722
Languefr
Fait partie deWorld Journal of Pharmaceutical Sciences
SujetGreen chemistry
SujetDimethylformamide-diiodine complex (DMF.I2)
Sujettrypanosomal infections
Sujetarylthiosemicarbazides
Sujetthiosemicarbazones
TitreN,Ndimethylformamide.diiodine complex (DMF.I2) as an innovative efficient green catalyst in the synthesis of thiosemicarbazones by condensation of ketones with thiosemicarbazides
TypeArticle

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