Effects of ethanolic extract of Ficus umbellata leaves on lipid parameters and liver, kidney and heart function in obese Wistar rats

Abstract

ABSTRACT: The present study aims to evaluate the effect of the ethanolic extract of the leaves of Ficus umbellata on lipid parameters and on hepatic, renal and cardiac function in obese Wistar rats. The result of the phytochemical screening carried out on this extract from the leaves of Ficus umbellata showed the presence of various compounds, in particular phenolic compounds, flavonoids, catechin tannins, leuco-anthocyanins, alkaloids, saponosides, anthraquinones, mucilages and sterols and terpenes. A significant decrease in body weight, plasma and tissue lipids was noted; in addition, the level of parameters such as urea, uric acid, AST, ALT and creatinine also decreased in rats treated with doses of 100, 300 and 500 mg/kg BW. Histologically, this study did not reveal any hepatic, renal or cardiac damage for the doses used