Syncytin-2: a potential early marker of preeclampsia. Revue international des Sciences Appliquées

Simple item page
AuteurLOKOSSOU, ADJIMON GBENAKPON GATIEN
AuteurDAVITO, LUCIEN
AuteurBADAROU, AMYRATH
AuteurACCROMBESSI, MANFRED M K
AuteurAZONNAKPO, JULIEN
AuteurKOUNOUDJI, GISCARDE
AuteurLOSEZ, EVELYNE JOSETTE MARIE
AuteurHOUNKPATIN, BENJAMIN IGNACE BODOUNRIN
AuteurPERRIN, RENE XAVIER
AuteurBABA MOUSSA, LAMINE SAID
AuteurBARBEAU, BENOIT
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2018
ResumeSyncytin-2 is an envelope protein that plays a key role in placental formation through the fusion of villous cytotrophoblasts (CTV), which leads to the formation of the syncytiotrophoblast (ST). The syncytiotrophoblast plays a key role in the function of the placenta. Defects in syncytiotrophoblast formation are associated with marked reduction in the expression of syncytin-2 and with placental pathologies such as preeclampsia (PE). Pre-eclampsia is responsible for a large number of maternal and fetal mortality and morbidity. However, there is no biomarker allowing an early diagnosis of PE. Since syncytin-2 is involved in placental formation, we decided to compare the abundance of syncytin-2 in serum derived-exosomes of pregnant women with pre-eclampsia vs normal pregnant women. We selected 44 pregnant women in a pre-eclampsia cohort at the Centre Hospitalier Universitaire-Mère et Enfant de la Lagune (CHU-MEL) in Cotonou. Women were recruited at the beginning of their pregnancy for the first 20 weeks of gestation and included 22 normal pregnant women and 22 pregnant women with PE. Serum derived-exosomes were purified and their content was analyzed. Lower abundance in syncytin-2 was measured in serum derived-exosomes of pregnant women with PE compared to those of normal pregnant women. This difference was observed between 9.6 and 13 weeks of gestation (p<0.05). This study confirms that syncytin-2 is a promising marker for early diagnosis of pre-eclampsia.
Autre identifiantBECDB-7936
URIhttps://dspace.uac.bj/handle/123456789/7129
Languefr
Fait partie deRevue Internationale des Sciences Appliquées
SujetPreeclampsia
SujetEarly diagnosis
Sujetexosomes
Sujetsyncytine-2
TitreSyncytin-2: a potential early marker of preeclampsia. Revue international des Sciences Appliquées
TypeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
af17220ca31d4cc2df8d7b35edb6b094.pdf
Size:
590.07 KB
Format:
Adobe Portable Document Format
Download

Collections

Articles