Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin

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AuteurAKPOVI, DEWANOU CASIMIR
AuteurSEGBO, JULIEN AUGUSTIN GAETAN
AuteurMEDEHOUENOU, THIERRY COMLAN MARC
AuteurANAGO, AHOEFA AMELE EUGENIE
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2015
ResumeBackground: Abnormal lipid profile is common in subjects with type 2 diabetes (T2D). Despite use of lipid- lowering agents, many subjects with T2D do not achieve lipid targets. The present work aimed to assess lipid profile in a randomly selected group of adult diabet ic subjects under treatment in order to determine how diabetes treatment affects blood lipid parameters levels. HbA1c level is used as a biomarker of glycaemia control achievement and treatment success in diabetic. Methods: This study was carried out as a pre-post test design study with a control group. A total of 117 diabetic subjects under treatment and 100 non-diabetics as control subjects are included in the study. TC, TG and HDL- C were measured by enzymatic methods and LDL-C was determined by Friedewald formula. Plasma glucose was measured by Glucose Oxidase method and glycated hemoglobin (HbA1c) with a radioimmunoassay. Results: The results showed that TC (p<0.001), LDLc (p<0.001) and TG (p=0.02) levels increased significantly in diabetics compared to controls. Atherogenic indices TC/HDL-C (p<0.01) and LDL-C/HDL-C (p<0.01), and blood calcium level (p<0.001) were significantly increased in diabetics than in controls. Subjects with HbA1c value >7.0% had significantly higher levels of TC (P<0.01), LDL-C (p<0.05), TC/HDL-C (p<0.01), LDL- C/HDL-C (p=0.02), TG/HDL-C (p=0.01) and calcemia (p<0.001) compared to subjects with HbA1c ≤7.0%. Conclusion: Significant difference of lipid parameters was observed in diabetics with HbA1c ≤7.0% and >7.0%. Abnormal lipid patterns and insulin resistance tend to be normalized with therapy of diabetes.
DOI10.7439/ijbr
Autre identifiantBECDB-3680
URIhttps://dspace.uac.bj/handle/123456789/3631
Languefr
Fait partie deInternational Journal of Biomedical Research
SujetType 2 diabetes
SujetHbA1c
Sujetlipid parameter
Sujetinsulin resistance
SujetBénin
TitreLipid profile in type 2 diabetic subjects aged 40 years and over living in Benin
TypeArticle

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