Interest of Prevention of Immediate Postpartum Hemorrhage with Misoprostol during Cesarean Section

Simple item page
AuteurVODOUHE, MAHUBLO VINADOU
AuteurTONATO EPSE BAGNAN, JOSIANE ANGELINA ADJOUA
AuteurHOUNKPATIN, BENJAMIN IGNACE BODOUNRIN
AuteurOBOSSOU, AWADE AFOUKOU ACHILLE
AuteurSIDI, IMOROU RACHIDI
AuteurPERRIN, RENE XAVIER
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2016
ResumeObjective: The purpose of this study was to compare the efficacy of sublingual misoprostol to oxytocin for the prevention of Immediate Postpartum Hemorrhage (IPPH) during caesarian section in the Borgou Regional University Teaching Hospital (CHUDB). Methods: It was a prospective randomized controlled clinical trial conducted over a period of 6 months from January 26 to July 26, 2015, on 230 female patients meeting inclusion criteria: cesarean section on term singleton pregnancy, under spinal anesthesia, without any bleeding. The patients were selected at random and divided into two groups: the first group had received 600 micrograms (μg) of misoprostol by sublingual route during umbilical cord clamping; the second one was administered 20 UI of oxytocin through intravenous route. The primary endpoint was drop in hematocrit. The secondary endpoints were drop in hemoglobin level, perioperative blood loss and postoperative complications. Findings: The socio-demographic and obstetrical characteristics of both groups’ patients were comparable. Average drop in hematocrit was identical: 0.05 ± 0.04 in both groups (p=0.573). The same applies to mean hemoglobin level: 1.7 ± 1.2 g/dl (p=0.886). As well, no significant difference was noted in average blood loss between the misoprostol group and the oxytocin group, respectively 281.8 ± 124.4 ml and 282.2 ± 120.8 ml (p=0.271). The incidence of side effects such as fevers and chills was significantly higher in the misoprostol group, respectively (79.1% vs. 9.6% and 79.1% vs. 0.0% p<0.001). However, those side effects were tolerable. Conclusion: 600 μg of misoprostol dose by sublingual route is also as effective as oxytocin in the prevention of postpartum hemorrhage without significant side effects.
DOI10.4172/2090-7214.1000250
Autre identifiantBECDB-4697
URIhttps://dspace.uac.bj/handle/123456789/4405
Languefr
Fait partie deClinics in Mother and Child Health
SujetCesarean section
SujetSublingual misoprostol
Sujetprévention
SujetPostpartum hemorrhage
TitreInterest of Prevention of Immediate Postpartum Hemorrhage with Misoprostol during Cesarean Section
TypeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
6fc8779976bd93b8d440a25171b95769.pdf
Size:
424.11 KB
Format:
Adobe Portable Document Format
Download

Collections

Articles