Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation and In Vitro Activity of Alkaloids Isolated from Holarrhena floribunda Used in Traditional Treatment of Buruli Ulcer

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AuteurYEMOA, LOCONON Y ACHILLE
AuteurGBENOU, JOACHIN D
AuteurAFFOLABI, DISSOU
AuteurMANSOUROU, MOUDACHIROU
AuteurBIGOT, KOFFI ANDRE
AuteurANAGONOU YEHOUENOU, C SEVERIN
AuteurPORTAELS, FRANCOISE
AuteurMARTIN, ANANDI
AuteurQUETIN LECLERCQ, JOELLE
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2015
ResumeBuruli ulcer (BU) imposes a serious economic burden on affected households and on health systems that are involved in diagnosing the disease and treating patients. Research is needed to find cost-effective therapies for this costly disease. Plants have always been an important source of new pharmacologically active molecules. Consequently we decided to undertake the study of plants used in traditional treatment of BU in Benin and investigate their antimycobacterial activity as well as their chemical composition. Extracts from forty-four (44) plant species were selected on account of reported traditional uses for the treatment of BU in Benin andwere assayed for antimycobacterial activities. Crude hydroethanolic extract fromaerial parts ofHolarrhena floribunda (G.Don) T. Durand and Schinz was found to have significant antimycobacterial activity againstM. ulcerans (MIC = 125
DOI10.1155/2015/835767
Autre identifiantBECDB-617
URIhttps://dspace.uac.bj/handle/123456789/972
Languefr
Fait partie deBioMed Research International
SujetBuruli ulcer
SujetMedicinal plants
SujetAntimycobacterial Agents
SujetBioguided Fractionation
Sujetin vitro
SujetAlkaloïds
TitreBeninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation and In Vitro Activity of Alkaloids Isolated from Holarrhena floribunda Used in Traditional Treatment of Buruli Ulcer
TypeArticle

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