Volatile oil composition and antiproliferative activity of Hyptis spicigera Lam against human breast adenocarcinoma cells MCF-7

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AuteurBOGNINOU AGBIDINOUKOU, G SOPHIE
AuteurYEDOMONHAN, HOUNNANKPON
AuteurAVLESSI, FELICIEN
AuteurSOHOUNHLOUE, KOKO CODJO DOMINIQUE
AuteurCHALARD, PIERRE
AuteurCHALCHAT, JEAN C
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2013
ResumeThis study reported the chemical composition and the evaluation of the in vitro antiproliferative activity of volatile extracts of Hyptis spicigera (HS) on breast cancer cells MCF-7. Essential oils (EO) HS1 and HS2 extracted from leafy stems of H. spicigera by hydrodistillation after different harvesting periods were characterized by gas chromatography/flame ionization detector (GC/FID) and gas chromatography/mass spectrometry (GC/MS). The cytotoxicity of these volatile extracts was tested in order to assess their antiproliferative activity on cancer cells MCF-7 by the resazurin test. Chromatographic analysis revealed several major compounds depending on the harvest period of vegetable. Sample HS1 was characterized by -pinene (16.9%), sabinene (13.8%), -pinene (9.6%) and 1,8-cineole (9.6%), while HS2 was potentially rich in - caryophyllene (53.2%), caryophyllene oxide (5.4%) and -humulene (3.8%). Biological investigations performed have shown that HS1 and HS2 were cytotoxic against MCF-7 cells. Inhibitory concentrations values (IC50) determined for this purpose were 170 and 84 μg/mL respectively for HS1 and HS2. Major compounds of the EO should be responsible for this inhibitory activity.
Autre identifiantBECDB-1852
URIhttps://dspace.uac.bj/handle/123456789/1939
Languefr
Fait partie deResearch Journal of Chemical Sciences
SujetHyptis spicigera
Sujetvolatile extract
SujetMCF-7
Sujet-caryophyllene
Sujet-pinene
SujetBénin
TitreVolatile oil composition and antiproliferative activity of Hyptis spicigera Lam against human breast adenocarcinoma cells MCF-7
TypeArticle

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