Promising Personalized Anti-Cancer Therapy: the Hidden Molecular Paths for Lamin A/C Deficiency and Restoration

Abstract

Carcinogenesis is a complex mechanism that often involves the silencing of cell differentiation and tumor suppressor gene transcripts or proteins while upregulating gene transcripts and proteins involved in cell proliferation and migration. This review focuses on different molecular pathways involved in the suppression of LMNA gene transcripts and lamin A/C proteins known to play important functions in epithelial cells including cell differentiation, gene transcription, cell growth regulation, cell cycle progression and regulation of migration. The restoration of lamin A/C proteins in cancer can only be possible if the mechanism leading to their disappearance is delineated prior to therapy.