Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns.

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AuteurLOKOSSOU, ADJIMON GBENAKPON GATIEN
AuteurDECHAVANNE, CELIA
AuteurBOURAIMA, AZIZ
AuteurCOURTIN, DAVID
AuteurLE PORT, AGNES
AuteurLADEKPO, RODOLPHE
AuteurNOUKPO, JULIEN M
AuteurBONOU, DESIRE
AuteurAHOUANGNINOU, CLAUDE
AuteurSABBAGH, AUDREY
AuteurFAYOMI, BENJAMIN
AuteurMASSOUGBODJI, ACHILLE A
AuteurGARCIA, ANDRE
AuteurMIGOT NABIAS, FLORENCE
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2013
ResumeBackground Particular cytokine gene polymorphisms are involved in the regulation of the antibody production. The consequences of already described IL-4, IL-10 and IL-13 gene polymorphisms on biological parameters and antibody levels were investigated among 576 mothers at delivery and their newborns in the context of P. falciparum placental malaria infection. Methods The study took place in the semi-rural area of Tori-Bossito, in south-west Benin, where malaria is meso-endemic. Six biallelic polymorphisms were determined by quantitative PCR using TaqMan® Pre-Designed SNP Genotyping Assays, in IL-4 (rs2243250, rs2070874), IL-10 (rs1800896, rs1800871, rs1800872) and IL-13 (rs1800925) genes. Antibody responses directed to P. falciparum MSP-1, MSP-2, MSP-3, GLURP-R0, GLURP-R2 and AMA-1 recombinant proteins were determined by ELISA. Results The maternal IL-4−590*T/IL-4+33*T haplotype (one or two copies) was associated with favorable maternal condition at delivery (high haemoglobin levels, absence of placental parasites) and one of its component, the IL-4−590TT genotype, was related to low IgG levels to MSP-1, MSP-2/3D7 and MSP-2/FC27. Inversely, the maternal IL-10−1082AA was positively associated with P. falciparum placenta infection at delivery. As a consequence, the IL-10−819*T allele (in CT and TT genotypes) as well as the IL-10−1082*A/IL-10−819*T/IL-10−592*A haplotype (one or two copies) in which it is included, were related to an increased risk for anaemia in newborns. The maternal IL-10−1082AA genotype was related to high IgG levels to MSP-2/3D7 and AMA-1 in mothers and newborns, respectively. The IL-13 gene polymorphism was only involved in the newborn’s antibody response to AMA-1. Conclusion These data revealed that IL-4 and IL-10 maternal gene polymorphisms are likely to play a role in the regulation of biological parameters in pregnant women at delivery (anaemia, P. falciparum placenta infection) and in newborns (anaemia). Moreover, IL-4, IL-10 and IL-13 maternal gene polymorphisms were related to IgG responses to MSP-1, MSP-2/3D7 and MSP-2/FC27 in mothers as well as to AMA-1 in newborns.
DOI10.1186/1471-2334-13-215
Autre identifiantBECDB-4112
URIhttps://dspace.uac.bj/handle/123456789/3941
Languefr
Fait partie deBMC infectious Diseases
SujetMalaria
SujetP. falciparum
SujetCytokine gene polymorphisms
SujetIL-4
SujetIL-10
SujetIL-13
SujetPregnancy
SujetCord blood
SujetRecombinant proteins
SujetSpecific antibodies
TitreAssociation of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns.
TypeArticle

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