Hormone Sensitive Breast Cancers: Histological and Immuno histochemical Aspects at CHU-MEL and Hubert Koutoukou MAGA National Teaching Hospital (CNHU-HKM) of Cotonou-Benin......

Abstract

Introduction: Breast cancer is a true public health problem; it is the first cause of female mortality from cancer in the world. Objective: To study the epidemiological, clinical and immunohistochemical characteristics of patients with a hormone sensitive breast cancer (hormone dependent breast cancer). Material and methods: It was a retrospective, descriptive and analytical study from 01/2013 to 01/2016, concerning the patients who had a mammary tumor exploration. Were regarded as hormone sensitive breast cancers those which expressed estrogen receptor(ER), progesterone receptor (PR) and HER2 oncoprotein. Results: Forty-three patients (43) patients had a medical examination for a breast cancer confirmed by an anatomopathological and immunohistochemical examination; 12 patients (27.90%) had a triple negative type breast cancer and 31 (72.09%) had a hormone sensitive cancer. The average age was 49.91 years. The nodule discovered by self-examination was the main reason for the discovery of the tumor with a period of time of 10 months before the first medical consultation. Sixty-one per cent (61.3%) of the patients had tumors classified T4 with palpable lymphadenopathy N1 (67.7%) without metastasis for most of them (M0). The classified subtypes were luminal A (74.19%) and B (25.80%). The invasive ductal carcinoma (90.3%) was the most common with a SBRII histoprognosis grade. Conclusion: Hormone sensitive breast cancers represented the majority of the breast cancers studied in our series. The diagnosis was late. The anatomopathological and immunohistochemical examinations were essential to classify this sub-type of breast cancer.