Impact des extraits éthyliques des feuilles de Hexalobus Monopetalus sur le métabolisme protéique des rats Wistar

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AuteurBEHANZIN, GBESSOHELE JUSTIN
AuteurAKOTEGNON, RODRIGUE
AuteurMICHODJEHOUN, LOETITIA
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2018
ResumeThe aim of this study was to evaluate the impact of the ethyl extract of dried leaves of Hexalobus monopetalus on protein metabolism in Wistar rats. After a phytochemical screening of extracts, total protein, urea, uric acid and creatinine were measured spectrophotometrically at six (06) sets of three (03) Wistar rats each. Batches 2 to 6 were given with orally administered respectively the daily doses of: 0.25 mg / kg, 0.5mg / kg, 1mg / kg, 1.5mg / kg and 2.5mg kg body weight of the extracts (for 14 days). The lot1 witness received distilled water instead of the extract. The results of the phytochemical screening revealed the presence polyphenolic compounds (gallic tannins, catechin tannin or condensed, anthocyanins, and leuco anthocyanins), flavonoids, mucilages reducing compounds, alkaloids, certain anthracene derivatives ( free anthracene, the O-glycosides), Steroids, and quinone derivatives. It was observed a significant increase (p ˂ 0.05) blood levels of total protein and uric acid and a significant (p ˂ 0.05) blood urea and creatinine levels in treated plots to extracts. These observed variations did not depend on the administered dose of the extracts but were depending on the duration of treatment; they were outstanding from the 7th day of treatment. The long term use of ethyl extract of dried leaves of Hexalobus monopetalus could compromise the liver function and the kidneys and may inhibit apoptosis in Wistar rats.
DOI10.14741/ijmcr.v6i01.10900
Autre identifiantBECDB-10614
URIhttps://dspace.uac.bj/handle/123456789/9455
Languefr
Fait partie deInternational Journal of Multidisciplinary and Current Research (IJMCR)
SujetHexalobus monopetalus
Sujetprotein
SujetUrea
Sujetcreatinine
Sujeturic acid
TitreImpact des extraits éthyliques des feuilles de Hexalobus Monopetalus sur le métabolisme protéique des rats Wistar
TypeArticle

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