Haspin: a promising target for the design of inhibators as potent anticancers drugs

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AuteurAMOUSSOU, NATHALIE GISELE
AuteurBIGOT, KOFFI ANDRE
AuteurROUSSAKIS, CHRISTOS
AuteurROBERT, JEAN MICHEL H
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2017
ResumeProtein kinases constitute a large group of enzymes in eukaryotes and have an important role in many cellular processes. Several of these proteins are active kinases, such as haploid germ cell-specific nudear protein kinase (Haspin), an atypical eukaryotic protein kinase that lacks sequence similarity with other eukaryotic protein kinases. Haspin is a serine/threonine kinase that associa tes with chromosome and phosphorylates threonine 3 of histone 3 during mitosis. Haspin overexpression or deletion results in defective mitosis. It has been shown that Haspin inhibitors have potent anti-tumoral effects. Given that the only Haspin substrate is threonine 3 of histone 3, inhibition of Haspin might have fewer adverse QZ effects compared with XXXX. Here, we highlight the chemical structures and actions of currently known Haspin inhibitoTs.
Autre identifiantBECDB-7178
URIhttps://dspace.uac.bj/handle/123456789/6475
Languefr
Fait partie deDrug Dlseovery TodaY
SujetHaspin
Sujetinhibators
Sujetanticancers
Sujetdrugs
TitreHaspin: a promising target for the design of inhibators as potent anticancers drugs
TypeArticle

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