SELECTIVE TRYPANOCIDE ACTIVITY OF SOME SUBSTITUTED THIOSEMICARBAZONES OF CITRAL FROM BENIN CYMBOPOGON CITRATUS ESSENTIAL OIL AND THEIR TOXICITY AGAINST ARTEMIA SALINA LEACH.

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AuteurSAKIRIGUI, AMOUSSATOU
AuteurKPOVIESSI, DOSSOU SIKA SALOME
AuteurGBAGUIDI, AHOKANNOU FERNAND
AuteurKOSSOUOH, COSME
AuteurBERO, JOANNE
AuteurQUETIN LECLERCQ, JOELLE
AuteurMANSOUROU, MOUDACHIROU
AuteurPOUPAERT, JACQUES H
AuteurACCROMBESSI, COFFI GEORGES
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2012
ResumeExtraction and analysis GC/FID and GC/MS showed that citral (neral + geranial) is the major compound of the essential oil of Benin Cymbopogoncitratus. This aldehyde was used as target for the hemi-synthesis in situ of the semicarbazone and substituted thiosemicarbazones. Their structures were confirmed by spectrometric analysis IR, 1H and 13C NMR. Their antiparasitic activities have been evaluated on Trypanosomabruceibrucei by determining their half-inhibitory concentrations (IC50). Among them, citral 4-phenyl-3-thiosemicarbazone (IC50 = 1.96 µM) and citralthiosemicarbazone (IC50 = 7.6 µM) showed a strong trypanocidal activity. Citral 2-methyl-3thiosemicarbazone (IC50 = 60.87 µM) showed a moderate activity. Citral 4-methyl-3-thiosemicarbazone (IC50 = 172.84 µM) and citralsemicarbazone (IC50 = 234.64 µM) were less actives. Toxicity test against Artemiasalina indicated that citral 4-phenyl-3-thiosemicarbazone is the most toxic compound (LC50 = 70.70 µM). The toxicities of other compounds are low. Citral 4-phenyl-3-thiosemicarbazone could have excellent anti-cancer properties. The selectivity index calculated from these data showed that all the molecules obtained are selective about the parasites Trypanosomabruceibrucei.
Autre identifiantBECDB-1609
URIhttps://dspace.uac.bj/handle/123456789/1746
Languefr
Fait partie deInternational Journal of Research and Reviews in Applied Sciences
SujetCymbopogoncitratus
SujetEssential oïl
Sujetcitral
Sujetthiosemicarbazones
Sujetspectrometrical analysis
Sujetantiparasitic activities
SujetTrypanosomabruceibrucei
SujetArtemiasalina
Sujetselectivity index
TitreSELECTIVE TRYPANOCIDE ACTIVITY OF SOME SUBSTITUTED THIOSEMICARBAZONES OF CITRAL FROM BENIN CYMBOPOGON CITRATUS ESSENTIAL OIL AND THEIR TOXICITY AGAINST ARTEMIA SALINA LEACH.
TypeArticle

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