Evaluation of antiradical and antibacterial activities of hydroethanolic extract of Spondias mombin leaves from Benin

Abstract

Spondias mombin is a plant species traditionally used in Benin in the treatment of many infections such as salmonellosis and urinary tract infections. In order to provide a scientific basis for this use, this work aims the biological and chemical valorization of S. mombin. After the phytochemical screening of the hydroalcoolic extract, the contents of phenolic compounds were evaluated and the antibacterial and anti-free radical activities were determined. The results obtained reveal, the presence of several metabolites such as tannins, flavonoid, coumarins, reducing compounds and anthraquinones known for their variable biological activities. The contents of total phenolic compounds (40,68 mgEqAG/gMS) and flavonoids (228.40 mgEqQ/gMS) are very interesting. The anti-radical activity of this extract is very high with an IC50<0.007 mg/mL compared to that of ascorbic acid (2.84 mg / ml). An interesting antibacterial activity was noted on the resistant strains of Streptococcus D, Staphylococcus aureus, Klebsiella pneumoniae and Citrobacter Sp. These good antioxidant and antimicrobial properties could be related to the presence of secondary metabolites and confirm the traditional use of S. mombin as traditional antioxidant and antibacterial agent.