Kinetics of Cytokines and Anti-SARS-CoV-2 Spike Glycoprotein S1 IgM and IgG1 in COVID-19 Infected Patients in Togo

Simple item page
AuteurKATAWA, GNATOULMA
AuteurHALATOKO, WEMBOO
AuteurKOBA, ADJAHO K
AuteurTCHOPBA, CHRISTELE NGUEPOU
AuteurTCHADIE, EDLOM P
AuteurSIMFELE, HOMBAMANE C
AuteurAMESSOUDJI, OUKOE M
AuteurADJOBIMEY, TOMABU
AuteurRITTER, MANUEL
AuteurDORKENOO, AMEYO M
AuteurKOLOU, MALEWE
Date d'ajout2026-06-02T16:06:57Z
Date de disponibilite2026-06-02T16:06:57Z
Date de publication2024
ResumeBackground: COVID-19, caused by, had spread throughout the world. Its clinical manifestations ranged from asymptomatic to severe forms. The immunological markers that determine these forms are poorly investigated in Togo. This study aimed to investigate the dynamics of antibodies and cytokines in COVID-19 infected patients in Togo. Methodology: Sera from symptomatic (n = 40) and asymptomatic (n = 40) patients, collected at Day0, Day3 and Day10 post admission, were analyzed for SARS-CoV-2 specific IgM and IgG1 antibodies and IL-1b, IL-6, TNFa, IL-5, IL-10, IL-17A and IFNg by sandwich ELISA. Results: In response to SARS-CoV-2 infection, IgM was expressed first followed by IgG1 in symptomatic patients. However, in asymptomatic patients, these antibodies were expressed simultaneously from the beginning of the infection with higher titers of IgG1. Except of IL-1b that increased from the admission to D10 all other cytokines were elevated at the admission and decreased to D10. Serum IL-6 levels were three times higher in symptomatic compared to asymptomatic patients. Conclusion: COVID-19 asymptomatic patients were characterized by high IgG1 antibodies titers whereas COVID-19 symptomatic patients, by high IL-6 levels.
DOI10.29011/2577-1515.100242
Autre identifiantBECDB-16147
URIhttps://dspace.uac.bj/handle/123456789/13593
Languefr
Fait partie deInfectious Diseases Diagnosis & Treatment
SujetCOVID-19
SujetAntibodies
SujetCytokines
SujetIgM
SujetIgG
SujetTogo
TitreKinetics of Cytokines and Anti-SARS-CoV-2 Spike Glycoprotein S1 IgM and IgG1 in COVID-19 Infected Patients in Togo
TypeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
a2cee2a96c7d34e413ed7d5694af55cf.pdf
Size:
702.22 KB
Format:
Adobe Portable Document Format
Download

Collections

Articles